Simultaneously Testing for Marginal Genetic Association and Gene-Environment Interaction
نویسندگان
چکیده
منابع مشابه
Simultaneously testing for marginal genetic association and gene-environment interaction.
In this article, the authors propose to simultaneously test for marginal genetic association and gene-environment interaction to discover single nucleotide polymorphisms that may be involved in gene-environment or gene-treatment interaction. The asymptotic independence of the marginal association estimator and various interaction estimators leads to a simple and flexible way of combining the 2 ...
متن کاملPractice of Epidemiology Simultaneously Testing for Marginal Genetic Association and Gene- Environment Interaction
In this article, the authors propose to simultaneously test for marginal genetic association and gene-environment interaction to discover single nucleotide polymorphisms that may be involved in gene-environment or genetreatment interaction. The asymptotic independence of the marginal association estimator and various interaction estimators leads to a simple and flexible way of combining the 2 t...
متن کاملMutual Information for Testing Gene-Environment Interaction
Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved. In this report, we define gene-environment interactions as a stochastic dependence in the context of the effects of the genetic and environmental risk factors on the cause of phenotypic variati...
متن کاملTesting gene-environment interaction in large-scale case-control association studies: possible choices and comparisons.
Several methods for screening gene-environment interaction have recently been proposed that address the issue of using gene-environment independence in a data-adaptive way. In this report, the authors present a comparative simulation study of power and type I error properties of 3 classes of procedures: 1) the standard 1-step case-control method; 2) the case-only method that requires an assumpt...
متن کاملEntropy based genetic association tests and gene-gene interaction tests.
In the past few years, several entropy-based tests have been proposed for testing either single SNP association or gene-gene interaction. These tests are mainly based on Shannon entropy and have higher statistical power when compared to standard χ2 tests. In this paper, we extend some of these tests using a more generalized entropy definition, Rényi entropy, where Shannon entropy is a special c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2012
ISSN: 1476-6256,0002-9262
DOI: 10.1093/aje/kwr521